CHAPTER IV

WORLD MARKET DATA


1. Top Branded Pharmaceuticals Worldwide
1998 worldwide sales in $ millions

Rank

1997

Rank

Brand

Company

% Market

Share(E)

1997

1998 (E)

1

1

Zocor (simvastatin)

Merck

31

3575

3926

2

2

Losec (omeprazole)

Astra

NA

2845

3083

3

3

Prozac (fluoxetine)

Lilly

33

2559

2651


2. Leading Companies in 1998 Global Pharmaceutical Sales

Rank

Company

1998 Sales

US $ billions

% of Global Sales

% Growth year over year

1

Novartis

10.6

4.2

+5

2

Merck & Co.

10.6

4.2

+8

3

Glaxo Wellcome

10.5

4.2

+1

3. Pharmaceutical Companies in 1998 Global FT500

Rank 1998

Rank 1997

Company

Market Capitalisation

(US $ million)

5

8

Merck & Co

154753

6

22

Pfizer

148074

13

10

Novartis

108475

4. Leading Therapy Classes in 1998 Global Pharmaceutical Sales

Rank

Company

1998 Sales

US $ billions

% of Global Sales

% Growth year over year

1

Anti-ulcerants

12.9

5.1

+3

2

Cholesterol & triglyceride            reducers

9.6

3.8

+20

3

Antidepressants

9.4

3.7

+21

5. Pharma Sales in 12 Leading Markets ($ billion)1

Country

Year to March 1998

% Change2

North America

72.9

+11

US

68.7

+11

Canada

4.2

+11


6. World's Most Profitable Companies

RANK

COMPANY

PROFIT (1995)
($ Millions)

1

Merck

3335

2

Johnson & Johnson

2403

3

Eli Lilly

2291


7. NCEs Introduced Worldwide in 1995

Product

Originator

Activity / indication

17-1A MAb (Panorex)

Centocor (US)

Antibody/adjuvant for colorectal cancer

Abeciximab (ReoPro)

Centocor (US)

Antiplatelet antibody/angioplasty

Aimmugen

Fujisawa (Japan)

Hepatitis A vaccine


8.         Patent Expiry Dates of Some Drugs and Pharmaceuticals

GENERIC NAME

PATENT EXPIRY DATE

Abciximab

2015

Alandronate Sodium

2007

Alemtuzumb

2015


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